Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. (AM J Otolaryngol 2000;21:306-311. Reset filters. Journal Article. Albain KS, Swann RS, Rusch VR, et al. By continuing you agree to the use of cookies. Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. They were placed on your computer when you launched this website. 169 pts. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. Concomitant drugs in drug abuse. Concomitant chemoradiotherapy has led to promising results when combination chemotherapy regimens were used in the phase II setting. Conclusion:This combined chemoradiotherapy approach is safe and efficacious for advanced unresectable head and neck cancer. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. A total of 70 Gy was delivered over 6 weeks. Read and print from thousands of top scholarly journals. that matters to you. Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. Carboplatin (area under the curve of 6) was given as a 30-min infusion on d 1 and 28. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed The patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group. Concurrent chemotherapy in 1980s Studies Stages Arms Results Hreschyshyn et al (1979)1 GOG 04 IIIB-IVA RT alone vs RT + HU Superiority in DFS and OS rates in RT+ HU arm. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . This patient with concomitant rectal cancer refused further chest radiation after 20 Gy of a planned 60 Gy. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy vs. concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma (NPC). Purpose: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. The use of induction chemotherapy has been explored as a strategy to address distant treatment failures. The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. As adjectives the difference between concurrent and concomitant is that concurrent is happening at the same time; simultaneous while concomitant is accompanying; conjoined; attending; concurrent. Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. Saunders Company. Google Scholar To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. Published. The median and 1-yr overall-survival rates were 24.9 mo and 63.8%, respectively. Copyright © 2000 by W.B. You can change your cookie settings through your browser. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 However, PCI was delivered more frequently for the sequential group. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). Purpose: For patients with advanced head and neck cancer, various combined chemoradiotherapy regimens have been used to improve local control. 15,000 peer-reviewed journals. 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